– ?-AA peptide P6 (Cyclic ?-AA Peptide 6)
– ?-AA peptide P6 (Cyclic ?-AA P6) is a potent activator of E6 associated protein (E6AP). ?-AA peptide P6?can stimulate the self-ubiquitination of E6AP and E6AP-catalyzed substrate ubiquitination in reconstituted reactions?in vitro. ?-AA peptide P6 can also enhance the ubiquitination of E6AP substrates in the cell and accelerate their degradation by the proteasome.
– CC(C)C[C@H]1CN(CC(N)=O)C(=O)CCSCC2C=CC(=CC=2)C(=O)N[C@H](CN(CC(=O)N[C@H](CN(CC(=O)N[C@@H](CC2C=CC=CC=2)CN(CC(=O)N1)C(=O)CC1CC1)C(=O)CC1C=C(C=C(C=1)OC)OC)CC(C)C)C(=O)CC1=CC2=CC=CC=C2C=C1)CCCCN