Product Details
Product Name:
– TD-1473
Catalog Number:
– D70831
Field of Application:
– TD-1473 (Izencitinib, TD1473, JNJ 8398) is a potent, selective, oral gut-selective pan-JAK inhibitor with pKi of 10.0/10.0/8.8/9.5 for human recombinant JAK1, JAK2, JAK3 and TYK2.TD-1473 inhibited cytokine-induced phosphorylation of STAT1 in mouse primary colonic epithelial cells with pIC50 values for inhibition against IL-6, IFN? and IFN? were 7.3, 6.8 and 7.0.TD-1473 demonstrated JAK inhibitory activity in ex vivo mouse colon and human IBD patient colonic tissue.?TD-1473 (Izencitinib) is under development for the treatment of?ulcerative colitis.
CAS:
– [2051918-33-1]
Formular:
– C22H26N8
