Product Details
Product Name:
– IMP-1710
Catalog Number:
– D70509
Field of Application:
– IMP-1710 (IMP1710) is a potent, selective, covalent UCHL1 inhibitor with IC50 of 38 nM.IMP-1710 demonstrated exquisite selectivity in a cross-screening against 20 DUBs.IMP-1710 can profile activity of endogenous UCHL1 with excellent selectivity in cell types including endothelial cells (EA.hy926) and adenocarcinoma human alveolar basal epithelial cells (A549).IMP-1710 demonstrated >50% fibroblastmyofibroblast transition (FMT) inhibition (IC50=740 nM) in idiopathic pulmonary fibrosis (IPF), as well as ?SMA inhibition.IMP-1710 is a powerful and selective probe to explore UCHL1 activity with potential application to substrate identification, mode of action studies, and cellular target profiling.
CAS:
– [2383117-96-0]
Formular:
– C23H19N5O
SMILES:
– O=C(N1C2=CC=CC(C3=CNC4=NC=C(C#C)C=C34)=C2CC1)[C@H]5N(CCC5)C#N
