Product Details
Product Name:
– NH-23-C2
Catalog Number:
– D70648
Field of Application:
– NH-23-C2 (Caspase-2 inhibitor NH-23-C2) is a potent, selective and cell-permeable endogenous caspase-2 inhibitor, does not block caspase-3 or caspase-8.NH-23-C2 displays off-reactivity with cysteine and threonine proteases (cathepsins B, L, V, S).HCT116 cells were preincubated with NH-23-C2 inhibitor, MDM-2 cleavage was inhibited in a concentration-dependent manner (IC50 =3.11 ?M).NH-23-C2 selectively block caspase-2 activity and caspase-2-mediated MDM-2 cleavage.
Formular:
– C43H51N5O13
SMILES:
– O=C(O)CCC[C@H](NC([C@H]1NC2=C(C=CC=C2)C1)=O)C(N[C@@H]([C@H](OCC3=CC=CC=C3)C)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(COC(C4=C(C)C=CC=C4C)=O)=O)=O)=O)=O
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