Product Details
Product Name:
– TTC-352
Catalog Number:
– D70851
Field of Application:
– TTC352 is a synthetic selective estrogen mimic acts as estrogen receptor (ER) partial agonist for the treatment of endocrine-resistant breast cancer.TTC 352 yields an H-bond with Glu353, allows Asp351-to-helix 12 (H12) interaction, sealing ER?’s ligand-binding domain, recruiting E2-enriched coactivators, and triggering rapid ER?-induced unfolded protein response (UPR) and apoptosis.TTC-352 is a less potent full estrogen agonist compared to E2, allowing H12 to seal the LBD, which recruits many E2-enriched coactivators, and induces rapid ER?-mediated UPR and apoptosis.
CAS:
– [1607819-68-0]
Formular:
– C20H13FO3S
SMILES:
– S1C(=C(C2C=CC(=CC=2)F)C2C=CC(=CC1=2)O)OC1C=CC(=CC=1)O
