Product Details
Product Name:
– A-674563 HCl
Catalog Number:
– D65347
Field of Application:
– A-674563 is a potent and selective Akt1 inhibitor with Ki of 11 nM. A-674563 suppressed the activation of the NLRP3 inflammasome in cardiomyocytes following ?-adrenoceptor activation, suggesting that AKT1 is a critical regulator molecule upstream of the NLRP3 inflammasome. A-674563 suppresses CDK2 activity, inhibits human NSCLC cell growth more effectively than the pan-AKT inhibitor, MK-2206
CAS:
– [2070009-66-2]
Formular:
– C22H23CLN4O
SMILES:
– Cl[H].O(C1=C([H])N=C([H])C(=C1[H])C1C([H])=C([H])C2C(=C(C([H])([H])[H])N([H])N=2)C=1[H])C([H])([H])[C@]([H])(C([H])([H])C1C([H])=C([H])C([H])=C([H])C=1[H])N([H])[H]
