– AIM-100 is a small molecule inhibitor of Ack1 with an IC50 of 24 nM
IC50 value: 24 nM [3]
Target: Ack1
Ack1 inhibitor AIM-100 not only inhibited Ack1 activation but also suppressed AKT tyrosine phosphorylation, leading to cell cycle arrest in the G1 ph