– PIK-75 is a selective cell-permeable inhibitor of PI 3-kinase p110? (IC50 values are 5.8, 76 nM and 1.3 ?M at PI 3-kinase p110?, PI 3-kinase p110? and PI 3-kinase p110? respectively). Inhibits production of PIP2 and PIP3 in adipocytes, phosphorylation of