Product Details
Product Name:
– AZ5576
Catalog Number:
– D70230
Field of Application:
– AZ5576 (AZ-5576) is a potent, selective CDK9 inhibitor with an IC 50 <5 nM, decreases phosphorlyation of Ser2-RNAPII in cells with an IC 50 of 96 nM.AZ5576 downregulated Mcl-1 and MYC protein abundance across multiple tested DLBCL cell lines and in primary DLBCL cells.MYC sensitizes DLBCL cells to AZ5576, genetic downregulation of MYC in U-2932 and OCI-LY19 cells resulted in diminished susceptibility to AZ5576.AZ5576 dose-dependently downregulated MYC transcription of a luciferase reporter containing multiple canonical MYC-MAX-binding sites, an effect more pronounced compared with multi-CDK inhibitor dinaciclib.AZ5576 restricts growth of xenografted DLBCL tumors in vivo.
CAS:
– [2751721-40-9]
Formular:
– C21H24FN3O3
SMILES:
– O(C1C=C(F)C=CC=1C1=CC=NC(NC([C@H]2CCC[C@@H](NC(=O)C)C2)=O)=C1)C
