Product Details
Product Name:
– Belumosudil mesylate
Catalog Number:
– D60435
Field of Application:
– Belumosudil, also known as KD-025 and WHO11343, is an orally bioavailable inhibitor of ROCK-II that is greater than 200-fold selective over ROCK-I (IC50s = 105 nM and 24 ?M, respectively). Belumosudil (SLx-2119; 40 ?M) induces significant down-regulations of Tsp-1 and CTGF mRNA levels in PASMC.
CAS:
– [2109704-99-4]
Formular:
– C27H28N6O5S
SMILES:
– S(C([H])([H])[H])(=O)(=O)O[H].O(C([H])([H])C(N([H])C([H])(C([H])([H])[H])C([H])([H])[H])=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=NC([H])=C2C(C([H])=C([H])C([H])=C2N([H])C2C([H])=C([H])C3=C(C([H])=NN3[H])C=2[H])=N1
