Product Details
Product Name:
– BMS-986260
Catalog Number:
– D65287
Field of Application:
– BMS-986260 is a potent, selective, and orally bioavailable TGF?R1 inhibitor (IC50=1.6 nM). BMS-986260 demonstrated functional activity in multiple TGF?-dependent cellular assays, excellent kinome selectivity, favorable pharmacokinetic properties, and curative in vivo efficacy in combination with anti-PD-1 antibody in murine colorectal cancer (CRC) models.
CAS:
– [2001559-19-7]
Formular:
– C18H12CLFN6O
SMILES:
– ClC1=C(C([H])=C([H])C(=C1[H])C1=C(C2C([H])=C([H])C3=NC([H])=C(C#N)N3N=2)N(C([H])=N1)C([H])([H])C([H])([H])O[H])F
