Product Details
Product Name:
– CFI-400945
Catalog Number:
– D70300
Field of Application:
– CFI-400945 is a potent, highly selective PLK4 inhibitor with Ki of 0.26 nM and IC50 of 2.8 nM, does not significantly inhibits PLK1/2/3 at 50 uM; causes dysregulated centriole duplication, mitotic defects, and cell death in multiple cancer cell lines (A549 GI50=5 nM, OVCAR-3 GI50=18 nM); significantly inhibits human cancer xenografts; causes polyploidy, growth inhibition, and apoptotic death of murine and human lung cancer cells, despite expression of mutated KRAS or p53, produces supernumerary centrosomes and mitotic defects in lung cancer cells.
CAS:
– [1338806-73-7]
Formular:
– C33H34N4O3
SMILES:
– O=C1[C@]2(C3C([H])=C(C([H])=C([H])C=3N1[H])OC([H])([H])[H])C([H])([H])[C@@]2([H])C1C([H])=C([H])C2C(/C(/[H])=C([H])/C3C([H])=C([H])C(=C([H])C=3[H])C([H])([H])N3C([H])([H])[C@@]([H])(C([H])([H])[H])O[C@@]([H])(C([H])([H])[H])C3([H])[H])=NN([H])C=2C=1[H]
