Product Details
Product Name:
– CXCR6 inhibitor 81
Catalog Number:
– D70333
Field of Application:
– CXCR6 inhibitor 81 is a potent (EC50=40 nM) and selective orally bioavailable small molecule antagonist of human CXCR6 receptor;
Compound 81 displays >10-fold improvement in potency in both the ?-arrestin and cAMP assays (IC50 =40 and 540 nM, respectively) compared to ML339.
CXCR6 inhibitor 81 inhibits migration of SK-HEP-1 hepatoma cells in a dose dependent manner. Compound 81 has promising oral DMPK data, significantly decreases tumor growth in a 30-day mouse xenograft model of HCC.
CAS:
– [2579689-85-1]
Formular:
– C27H30F3N3O4S
SMILES:
– C(NC1CC2N(CC3=NC4=C(C(F)(F)F)C=CC=C4S3)C(CCC2)C1)(=O)C1=CC(OC)=C(OC)C(OC)=C1
