Product Details
Product Name:
– F5446
Catalog Number:
– D42710
Field of Application:
– F5446 is a SUV39H1 inhibitor. F5446 has an EC50 of 0.496 ?mol/L for SUV39H1 enzymatic activity. H3K9me3 was enriched in the promoters of GZMB, PRF1, FASLG, and IFNG in quiescent T cells. F5446 inhibited H3K9me3, thereby upregulating expression of these effectors in tumor-infiltrating CTLs and suppressing colon carcinoma growth in a CD8+ CTL-dependent manner in vivo. Our data indicate that SUV39H1 represses CTL effector gene expression and, in doing so, confers colon cancer immune escape.
CAS:
– [2304465-89-0]
Formular:
– C26H17ClN2O8S
SMILES:
– O=C(C1=CNC2=C1C3=C(N(S(=O)(C4=CC=C(Cl)C=C4)=O)C(C(OC)=O)=C3)C(C2=O)=O)OCC5=CC=CC=C5
