Product Details
Product Name:
– Foretinib(XL880)
Catalog Number:
– D7342
Field of Application:
– Foretinib (GSK1363089; XL880; EXEL-2880; GSK089) is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met and KDR with IC50 of 0.4 nM and 0.9 nM. Less potent against Ron, Flt-1/3/4, Kit, PDGFR?/? and Tie-2, and little activity to FGFR1 and EGFR.
CAS:
– [849217-64-7]
Formular:
– C34H34F2N4O6
SMILES:
– O=C(NC1=CC=C(C(F)=C1)OC2=C3C=C(C(OCCCN4CCOCC4)=CC3=NC=C2)OC)C5(CC5)C(NC6=CC=C(C=C6)F)=O
