– GN44028 inhibits HIF-1?. GN44028 surpresses HIF-1? transcriptional activity without affecting both HIF-1? protein accumulation and HIF-1?/HIF-1? heterodimerization in nuclei under the hypoxic conditions, suggesting that GN44028 probably affectes the transcriptional pathway induced by the HIF-1?/HIF-1? heterodimer.