Product Details
Product Name:
– GNE-0749
Catalog Number:
– D53043
Field of Application:
– GNE-0749 is a potent and selective pan-RAF inhibitor with Ki of 0.061 nM and <0.08 nM for CRAF and BRAF, respectively. Combinated with cobimetinib, GNE-0749 demonstrates synergistic pharmacodynamic effects in the KRAS mutant HCT116 tumor-bearing mice.
Formular:
– C23H27F2N5O2
SMILES:
– N(CCC(C)(C)C)C(NC1=CC(NC2C=CC3=C(C=2F)C(=O)N(C)C=N3)=C(C)C=C1F)=O
