Product Details
Product Name:
– GPS167
Catalog Number:
– D70440
Field of Application:
– GPS167 is a specific small molecule splicing regulator SRSF10 inhibitor, modulates BCLAF1 splicing with IC50 of 2 uM in human colorectal HCT116 cells, directly inhibits CLK1, CLK2 and CLK4, but not SRPK1 and DYRK1A.GPS167 promotes the dephoshorylation of SRSF10 and changes its interaction with partner proteins.GPS167 treatment leads to a partial dephosphorylation of SRSF10 and increases the recovery of CLK1 and CLK4.GPS167 impairs the growth of cancer cell line, elicits p53-dependent cytotoxicity.GPS167 is cytotoxic for human colorectal cancer organoids but not normal organoids.
Formular:
– C17H13N5OS
SMILES:
– O=C(C1=CSC(NC2=CC=CC=C2)=N1)NC3=CC4=C(NN=C4)C=C3
