Product Details
Product Name:
– Gramicidin S
Catalog Number:
– D60400
Field of Application:
– Gramicidin S is an anttiboitics. Gramicidin S reduces the cell number of planktonic cells within 20-40 min at a concentration of 40-80 ?g/mL. Gramicidin S kills the cells of pre-grown biofilms at concentrations of 100-200 ?g/mL, such that no re-growth is possible. The translocation of the peptide into the cell interior and its complexation with intracellular nucleotides, including the alarmon ppGpp, can explain its anti-biofilm effect. The successful treatment of persistently infected root canals of two volunteers confirms the high effectiveness of GS. The broad Gramicidin S activity towards resistant, biofilm-forming E. faecalis suggests its applications for approval in root canal medication.
CAS:
– [113-73-5]
Formular:
– C60H92N12O10
SMILES:
– NCCC[C@@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC2C=CC=CC=2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC2C=CC=CC=2)NC(=O)[C@H](CC(C)C)NC1=O
