Product Details
Product Name:
– GSK3494245
Catalog Number:
– D48830
Field of Application:
– GSK3494245 (DDD01305143) is a potent, orally active, and selective inhibitor of the chymotrypsin-like activity of the parasite proteasome binding in a site sandwiched between the ?4 and ?5 subunits (IC50=0.16 ?M for WT L. donovani proteasomes). GSK3494245 moderately inhibits chymotrypsin-like activity of human proteasome (IC50: purified 26S=13 ?M; enriched THP-1 extracts IC50=40?M). GSK3494245 exhibits attractive biological and biosafety properties.
CAS:
– [2080410-41-7]
Formular:
– C21H23FN6O2
SMILES:
– FC1C([H])=C([H])C(=C([H])C=1C1C([H])=C([H])N2C(N=1)=NC([H])=C2N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N([H])C(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])=O
