Product Details
Product Name:
– HM43239
Catalog Number:
– D60179
Field of Application:
– HM43239 is an orally active small molecule inhibitor of FLT3 that selectively inhibits not only FLT3 wild type, ITD mutants or TKD mutations, but also FLT3 ITD/TKD double mutations. HM43239 directly inhibits the kinase activity of FLT3 as a reversible Type I inhibitor and effectively modulates downstream p-STAT5 and p-ERK. HM43239 also demonstrated inhibition of SYK, JAK1/2 and TAK1, known to be involved in tumor cell proliferation and/or differentiation HM43239 monotherapy induced dose-dependent regression of tumor growth in FLT3 wild-type and FLT3 mutated leukemia cancer cell line.
CAS:
– [2294874-49-8]
Formular:
– C29H33CLN6
SMILES:
– ClC1=C([H])N=C(N=C1C1=C([H])N([H])C2C([H])=C(C([H])([H])[H])C([H])=C([H])C1=2)N([H])C1=C([H])C(C([H])([H])N2C([H])([H])[C@@]([H])(C([H])([H])[H])N([H])[C@@]([H])(C([H])([H])[H])C2([H])[H])=C([H])C(=C1[H])C1([H])C([H])([H])C1([H])[H]
