Product Details
Product Name:
– IACS-15414
Catalog Number:
– D70502
Field of Application:
– IACS-15414 (IACS 15414) is a potent, selective, orally bioavailable SHP2 inhibitor with IC50 of 122 nM;
IACS-15414 potently suppressed the mitogen-activated protein kinase (MAPK) pathway signaling and tumor growth in RTK-activated and KRASmut xenograft models in vivo.
IACS-15414 potently suppressed the mitogen-activated protein kinase (MAPK) pathway signaling and tumor growth.
IACS-15414 had excellent PK properties across species but a narrow hERG window.
CAS:
– [2411321-29-2]
Formular:
– C20H24CL2N4O2
SMILES:
– C1(C)=NC(N2CCC3(CO[C@@H](C)[C@H]3N)CC2)=CC(=O)N1C1=CC=CC(Cl)=C1Cl
