– IHMT-PI3K?-372 is a potent and selective PI3K? with an IC50 of 14 nM. IHMT-PI3K?-372 shows high selectivity over other class I PI3Ks (56?83 fold) and other protein kinases. IHMT-PI3K?-372 can be uesd for chronic obstructive pulmonary disease (COPD) research.