Product Details
Product Name:
– Isochlorogenic acid C
Catalog Number:
– D23034
Field of Application:
– 4,5-Dicaffeoylquinic acid ( Isochlorogenic acid C) possesses potent hepatoprotective and anti-HBV effects.IC50 value:Target: Anti-hepatitis natural produce.In vitro: To study anti-hepatitis effect of isochlorogenic acid C, anti-apoptotic and anti-injury properties of test compound were evaluated. The results showed that test compound at concentrations of 10 to 100 ?g/ml significantly reduced the caspase-3 and transformed growth factor ?1 (TGF?1) levels of the D-GalN-challenged hepatocytes. Also, test compound improved markedly cell viability of the D-GalN-injured hepatocytes and produced a maximum protection rate of 47.28% at a concentration of 100 ?g/ml. Furthermore, test compound significantly inhibited productions of HBsAg and HBeAg. Its maximum inhibitory rates on the HBsAg and HBeAg expressions were 86.93 and 59.79%, respectively. In addition, test compound significantly induced the HO-1 expression of HepG2.2.15 cells [1]. In vivo:
CAS:
– [57378-72-0]
Formular:
– C25H24O12
SMILES:
– O(C(/C(/[H])=C([H])/C1C([H])=C([H])C(=C(C=1[H])O[H])O[H])=O)[C@]1([H])C([H])([H])[C@@](C(=O)O[H])(C([H])([H])[C@]([H])([C@]1([H])OC(/C(/[H])=C([H])/C1C([H])=C([H])C(=C(C=1[H])O[H])O[H])=O)O[H])O[H]
