Product Details
Product Name:
– KSQ-4279 (Synonyms: USP1-IN-1)
Catalog Number:
– D60562
Field of Application:
– KSQ-4279 is a USP1 and PARP inhibitor. KSQ-4279 showed anti-proliferative effects in a subset of cell lines, often characterized by the presence of homologous recombination deficiencies (HRD), including mutations in BRCA1/2. The combination of KSQ-4279 with olaparib was able to induce strong and durable regressions across a number of ovarian and TNBC PDX models.
CAS:
– [2446480-97-1]
Formular:
– C27H25F3N8O
SMILES:
– C1(C2=C(OC)N=CN=C2C2CC2)=NC=C2C=NN(CC3=CC=C(C4N(C(C)C)C=C(C(F)(F)F)N=4)C=C3)C2=N1
