Product Details
Product Name:
– Lenacapavir(GS-6207)
Catalog Number:
– D65300
Field of Application:
– Lenacapavir, also known as GS-6207, is a HIV-1 capsid inhibitor. Lenacapavir shows anti-HIV activity. Lenacapavir displays a mean EC50 of 50 pM (20-160 pM) against 23 HIV-1 clinical isolates from different subtypes in peripheral blood mononuclear cells (PBMCs). Lenacapavir demonstrated picomolar potency in vitro with no cross resistance to existing antiretroviral classes and potent antiviral activity in persons with HIV-1. In persons with HIV-1, there was no preexisting resistance to lenacapavir regardless of treatment history.
CAS:
– [2189684-44-2]
Formular:
– C39H32CLF10N7O5S2
SMILES:
– ClC1C([H])=C([H])C(=C2C=1C(N([H])S(C([H])([H])[H])(=O)=O)=NN2C([H])([H])C(F)(F)F)C1C([H])=C([H])C(C#CC(C([H])([H])[H])(C([H])([H])[H])S(C([H])([H])[H])(=O)=O)=NC=1[C@]([H])(C([H])([H])C1C([H])=C(C([H])=C(C=1[H])F)F)N([H])C(C([H])([H])N1C2=C(C(C(F)(F)F)=N1)[C@@]1([H])C([H])([H])[C@@]1([H])C2(F)F)=O
