Product Details
Product Name:
– lipid 14
Catalog Number:
– D82125
Field of Application:
– LIPID 14 is a novel ionizable lipid used for mRNA delivery.In 2021, Elia et al. used lipid 2 LNPs and lipid 14 LNPs to deliver mRNA encoding SARSCoV-2 human Fc-conjugated receptor binding domain (RBDhFc
mRNA). While both lipid 274 LNP RBD-hFc mRNA and
lipid 14 LNP RBD-hFc mRNA induced equal cellular and
humoral responses in mice at an mRNA dose of 5 ?g, only lipid
14 LNP RBD-hFc mRNA exhibited strong immunogenicity
following intradermal administration. Both intradermal administration
and intramuscular administration of lipid 14 LNPs
could activate antigen presenting cells (APCs), thus inducing
cellular responses.
CAS:
– [2430034-05-0]
Formular:
– C56H110N2O6
SMILES:
– O=C(OCCN(CCCCCCCCOC(C(CCCCCC)CCCCCCCC)=O)CCCCCCCCOC(C(CCCCCC)CCCCCCCC)=O)CCCN(C)C
