– LY367385 is a highly potent and selective mGluR1a antagonist. LY367385 has an IC50 of 8.8 ?M for inhibits of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with > 100 ?M for mGlu5a. LY367385 has neuroprotective, anticonvulsant and antiepileptic effects.