Product Details
Product Name:
– ML372
Catalog Number:
– D23748
Field of Application:
– ML372 is a small molecule SMN modulator that increases SMN protein in patient fibroblasts with EC50 of 37 nM; possesses good potency, pharmacokinetics, tolerance, and CNS penetration that are able to increase levels of SMN protein in several model cell lines; increase SMN protein levels in vivo, restore motor function, and prolong survival of SMN?7 SMA Mice; improves the righting reflex and extended survival of a severe mouse model of SMA.
CAS:
– [1331745-61-9]
Formular:
– C18H20N2O4S
SMILES:
– O=C(O)C(CC1)CCN1C2=NC=C(S2)C3=CC(OCCCO4)=C4C=C3
