Product Details
Product Name:
– NAB-14
Catalog Number:
– D23617
Field of Application:
– NAB-14 is a potent, selective negative allosteric modulator of GluN2C/2D-containing NMDA receptors with IC50 of 580 nM, >800-fold selective over GluN2A/GluN2 receptors; inhibits triheteromeric (GluN1/GluN2A/GluN2C) NMDARs with modestly reduced potency and efficacy compared to diheteromeric (GluN1/GluN2C/GluN2C) receptors; inhibits GluN2D-mediated synaptic currents in rat subthalamic neurons and mouse hippocampal interneurons, but has no effect on synaptic transmission in hippocampal pyramidal neurons.
CAS:
– [1237541-73-9]
Formular:
– C20H21N3O3
SMILES:
– C(OC1=CC=C(C(=O)NC2C3=C(C=CC=2)C=CN3)C=C1)(=O)N(CC)CC
