Product Details
Product Name:
– NRX-252114
Catalog Number:
– D20252
Field of Application:
– NRX-252114 is a potent enhancer of the interaction between ?-catenin, and its cognate E3 ligase, SCF?-TrCP. NRX-252114 enhances the binding of pSer33/S37A ?-catenin peptide for ?-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. NRX-252114 induces mutant ?-catenin degradation.
CAS:
– [2763260-39-3]
Formular:
– C22H12CL2F3N3O2S
SMILES:
– C1C2=C(C(C#N)=CC=C2)CN1C(C1=C(SC2=C(Cl)C=CC=C2Cl)C=C(C(F)(F)F)NC1=O)=O
