Product Details
Product Name:
– ONO-7475
Catalog Number:
– D31007
Field of Application:
– ONO-7475 is a potent, selective, and orally active novel Anexelekto/MER tyrosine kinase inhibitor with IC50 values of 0.7 nM and 1.0 nM, respectively. ONO-7475 sensitizes AXL-overexpressing EGFR-mutant NSCLC cells to the EGFR-TKIs, suppresses the emergence and maintenance of tolerant cells. ONO-7475 combines with Osimertinib provides a bright promise for the study of EGFR-mutated non-small cell lung cancer (NSCLC).
CAS:
– [1646839-59-9]
Formular:
– C32H26N4O6
SMILES:
– O=C(NC1C=CC(OC2C3C(=CC(=C(C=3)OC)OC)N=CC=2)=CN=1)C1C(=O)N(C2C=CC=CC=2)C2CCCC(=O)C=2C=1
