– PARP10-IN-2 is a potent mono?ADP?ribosyltransferase PARP10 inhibitor with an IC50 of 3.64 ?M for human PARP10. PARP10-IN-2 reveals potent inhibition on PARP2 and PARP15 with IC50s of 27 ?M and 11 ?M for human PARP2 and human PARP15, respectively[1].