– ?-pBrPh-Glc is a small-molecule ice recrystallization inhibitor. ?-pBrPh-Glc can control the rate and extent of intracellular ice recrystallization in the nuclei over a broad range of subzero temperatures. ?-pBrPh-Glc is an important tool to improve the recovery and function of cryopreserved cells and tissues.