Product Details
Product Name:
– Pentixafor(CPCR4-2)
Catalog Number:
– D65338
Field of Application:
– Pentixafor is a ligand to make gallium Ga 68-pentixafor, a radioconjugate composed of a synthetic, cyclic pentapeptide analog of stromal-cell derived factor-1 (SDF-1 or CXCL12), which is a ligand for chemokine receptor C-X-C chemokine receptor type 4 (CXCR4), that is radiolabeled, via the macrocyclic chelating agent dodecanetetraacetic acid (DOTA), with the radioisotope gallium Ga 68 (Ga68; 68Ga), with potential use for imaging CXCR4-expressing cells upon positron emission tomography (PET)/computed tomography (CT). Upon administration of 68Ga-pentixafor, the pentixafor moiety targets and binds to CXCR4-expressing cancer cells. Upon PET/CT, CXCR4-expressing cancer cells can be visualized and the expression status of the receptor can be assessed. CXCR4, a marker of poorly differentiated cells, is overexpressed on various cancer cells, and plays a key role in tumor growth, progression, invasiveness and metastasi
CAS:
– [1341207-62-2]
Formular:
– C60H80N14O14
SMILES:
– O=C1[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])N([H])C(C2C([H])=C([H])C(=C([H])C=2[H])C([H])([H])N([H])C(C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])N(C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])N(C([H])([H])C(=O)O[H])C([H])([H])C2([H])[H])=O)=O)N(C([H])([H])[H])C([C@@]([H])(C([H])([H])C2C([H])=C([H])C(=C([H])C=2[H])O[H])N([H])C(C([H])([H])N([H])C([C@]([H])(C([H])([H])C2C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C3C=2[H])N([H])C([C@]([H])(C([H])([H])C([H])([H])C([H])([H])/N=C(N([H])[H])/N([H])[H])N1[H])=O)=O)=O)=O
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