Product Details
Product Name:
– PF-04802367
Catalog Number:
– D21484
Field of Application:
– PF04802367 is a potent, highly selective GSK-3 inhibitor with IC50 of 2.1 nM for human GSK-3? in enzyme assays; shows equal effectivity against GSK-3? and GSK-3? with IC50 of 10.0 and 9.0 nM respectively in mobility shift assays, inhibits phosphorylation of tau with an IC50 of 466 nM in a stable inducible CHO cell line over-expressing GSK-3? and substrate tau; modulates tau phosphorylation in?vitro and in?vivo.
CAS:
– [1962178-27-3]
Formular:
– C16H16CLN5O3
SMILES:
– ClC1=C(C=CC(=C1)C1=C(C(NCCCN2C=NC=N2)=O)N=CO1)OC
