Product Details
Product Name:
– PF-06835919
Catalog Number:
– D30002
Field of Application:
– PF-06835919, also known as MDK1846, is a potent ketohexokinase (KHK) inhibitor. PF-06835919 is reported in patent US 20170183328 A1, example 4. Increased fructose consumption and its subsequent metabolism have been implicated in hepatic steatosis, dyslipidemia, obesity, and insulin resistance in humans. Since ketohexokinase (KHK) is the principal enzyme responsible for fructose metabolism, identification of a selective KHK inhibitor may help to further elucidate the effect of KHK inhibition on these metabolic disorders.
CAS:
– [2102501-84-6]
Formular:
– C16H19F3N4O2
SMILES:
– FC(C1=CC(=NC(=N1)N1CC[C@@H]1C)N1C[C@H]2C(CC(=O)O)[C@H]2C1)(F)F
