Product Details
Product Name:
– Pirtobrutinib (LOXO-305)
Catalog Number:
– D50020
Field of Application:
– LOXO-305 is an investigational, novel, selective non-covalent Brutons tyrosine kinase (BTK) inhibitor. LOXO-305 was designed to reversibly bind BTK, preserve activity in the presence of the acquired resistance, and avoid off-target kinases that have complicated the development of both covalent and investigational non-covalent BTK inhibitors.LOXO-305 is a highly selective, non-covalent BTKi that inhibits both wild type (WT) and C481-mutated BTK with equal low nM potency was developed.
CAS:
– [2101700-15-4]
Formular:
– C22H21F4N5O3
SMILES:
– FC([C@H](C)N1C(=C(C(N)=O)C(C2C=CC(CNC(C3C=C(C=CC=3OC)F)=O)=CC=2)=N1)N)(F)F
