Product Details
Product Name:
– R-268712
Catalog Number:
– D8022
Field of Application:
– Potent and selective inhibitor of the TGF-? type I receptor/ALK5 (IC50 = 2.5 nM). Exhibits ~ 5000-fold selectivity over p38 MAPK. Suppresses development of renal fibrosis in a unilateral ureteral obstruction model. Also reduces proteinuria, glomeruloscler
CAS:
– [879487-87-3]
Formular:
– C20H18FN5O
SMILES:
– FC1C=CC(C2C(C3N=C(C)C=CC=3)=NNC=2)=CC=1C1C=NN(CCO)C=1
