Product Details
Product Name:
– RO 46-8443
Catalog Number:
– D33038
Field of Application:
– RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition. The observed parallel rightward shift of concentration-response curves with different antagonist concentrations is consistent with a competitive binding mode. Since R0 46-8443 selectively inhibits ETB receptor mediated responses, it is a valuable tool for clarifying the role of ETB receptors in pathology.
CAS:
– [175556-12-4]
Formular:
– C31H35N3O8S
SMILES:
– COC(C=CC=C1)=C1OC2=C(OCC(O)CO)N=C(C3=CC=C(OC)C=C3)N=C2NS(C4=CC=C(C(C)(C)C)C=C4)(=O)=O
