– Rosiglitazone maleate is a potent and selective activator of PPAR?, with EC50s of 30 nM, 100 nM and 60 nM for PPAR?1, PPAR?2, and PPAR?, respectively, and a Kd of appr 40 nM for PPAR?; Rosiglitazone maleate is also an modulator of TRP channels, inhibits T