– RSVA405 is a potent, orally active activator of AMPK, with an EC50 of 1 ?M. RSVA405 facilitates CaMKK?-dependent activation of AMPK, inhibits mTOR, and promotes autophagy to increase A? degradation. RSVA405 has anti-inflammatory effects through the inhibition of STAT3 function. RSVA405 also can be used for the research of obesity.