Product Details
Product Name:
– SMAD3
Catalog Number:
– D32519
Field of Application:
– SMAD3 is a receptor-regulated intracellular protein that functions downstream of TGF-? and activin receptors and mediates their signaling, playing a role in cell proliferation, differentiation, apoptosis and formation of extracellular matrix. Smad3 Inhibitor, SIS3 is a cell-permeable pyrrolopyridine compound that selectively inhibits TGF-?1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling with no effect on Smad2, p38 MAPK, ERK, or PI 3-K signaling. It has been shown to reduce TGF-?1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.
CAS:
– [1009104-85-1]
Formular:
– C28H27N3O3
SMILES:
– CN1C2C(=CC=CN=2)C(/C=C/C(N2CCC3=C(C=C(C(OC)=C3)OC)C2)=O)=C1C1=CC=CC=C1
