Product Details
Product Name:
– SR-0813
Catalog Number:
– D47894
Field of Application:
– SR-0813 is a potent and selective ENL/AF9 YEATS domain inhibitor. SR-0813 has IC50 and EC50 values of 25 nM and 205 nM for ENL YEATS domain, respectively. SR-0813 has IC50 and EC50 values of 311 nM and 76 nM (CETSA) for AF9 YEATS domain, respectively. SR-0813 binds MAP3K19 with over 100-fold lower affinity (Kd=3.5 ?M) than ENL YEATS (Kd=30 nM). SR-0813 can be used for the research of acute leukemia.
CAS:
– [2597186-19-9]
Formular:
– C25H32N6O3S
SMILES:
– S(NC1C=CC=C(C=1)C1=CN2C(C=CC(=C2)C(NC2CCC2)=O)=N1)(NCCN1CCCCC1)(=O)=O
