Product Details
Product Name:
– SSK1
Catalog Number:
– D65295
Field of Application:
– SSK1 is a senolytic prodrug, which was designed from gemcitabine, by chem. modifying gemcitabin to incorporate a site cleavable by SA-?-gal following delivery of the prodrug in vivo, to release the active parent drug gemcitabine. SSK1 can be used to reduce one or more symptoms associated with a Senescence-associated disease or disorder in a subject. SSK1 is specifically activated by ?-gal and eliminates mouse and human senescent cells independently of senescence inducers and cell types. In aged mice, SSK1 effectively cleared senescent cells in different tissues, decreased the senescence- and age-associated gene signatures, attenuated low-grade local and systemic inflammation, and restored physical function.
CAS:
– [2629250-69-5]
Formular:
– C31H34F2N4O18
SMILES:
– O(C1C=CC(COC(=O)NC2C=CN([C@H]3C([C@H](O)[C@@H](CO)O3)(F)F)C(=O)N=2)=CC=1N(=O)=O)[C@@H]1O[C@H](COC(=O)C)[C@H](OC(=O)C)[C@H](OC(=O)C)[C@H]1OC(=O)C
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