Product Details
Product Name:
– TG8-260
Catalog Number:
– D70837
Field of Application:
– TG8-260 is a second-generation, potent, selective EP2 antagonist with Schild KB of 13.2 nM.TG8-260 displays 500-fold selectivity to EP2 against other prostanoid receptors.TG8-260 has a plasma half-life of 2.14 h (PO) and excellent oral bioavailability (77.3%), TG8-260 is a potent inhibitor of CYP450 enzymes.TG8-260?displays antagonistic activity on the induction of EP2 receptor-mediated inflammatory gene expression in microglia BV2-hEP2 cells.TG8-260 reduces hippocampal neuroinflammation and gliosis after pilocarpine-induced status epilepticus in rats.TG8-260 is a tool for investigating anti-inflammatory pathways in peripheral inflammatory disease animal models.
CAS:
– [2490544-50-6]
Formular:
– C21H20N4O
SMILES:
– C(NCCC1C2=C(NC=1C)C=CC=C2)(=O)C1=CC=C(C2NC=NC=2)C=C1
