Product Details
Product Name:
– VK-II-86
Catalog Number:
– D70883
Field of Application:
– VK-II-86 is a carvedilol analogue lacking antagonist activity at ?-adrenoceptors, effectively suppresses SOICR by directly reducing the open duration of the cardiac ryanodine receptor (RyR2).VK-II-86 exhibited >2,000-fold lower beta-AR binding affinity than carvedilol.VK-II-86 prevented stress-induced ventricular tachyarrhythmias in RyR2-mutant mice and did so more effectively when combined with either of the selective beta blockers metoprolol or bisoprolol.VK-II-86 prevented hypokalaemia-induced AP prolongation and depolarization but did not alter AP parameters in normokalaemia.
CAS:
– [955371-84-3]
Formular:
– C25H28N2O4
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