Product Details
Product Name:
– Z-Arg-Lys-AOMK
Catalog Number:
– D70927
Field of Application:
– Z-Arg-Lys-AOMK is a potent, selective, irreversible neutral pH 7.2 inhibitor of Cathepsin B with IC50 of 13 nM, >100-fold higher potent than at pH 4.6 (IC50=1,830 nM).
Z-Arg-Lys-AOMK displayed high specificity for cathepsin B compared to other lysosomal cysteine cathepsins.
Z-Arg-Lys-AOMK selectively inhibits cathepsin B cleavage of peptides at neutral cytosolic pH compared to acidic lysosomal pH conditions.
Z-Arg-Lys-AOMK completely inhibited cathepsin B in human neuroblastoma cell lysates at 1 uM.
Z-Arg-Lys-AOMK is cell permeable and inhibits intracellular cathepsin B.
Formular:
– C30H42N6O6
